Peptic Ulcers, Shalya Tantra, BAMS 4th Year
PEPTIC ULCERS :
For the causation of peptic ulcers, a state of increased secretion of acid as well as pepsin, is a pre-requiste. Patients with duodenal ulcer have a higher average pepsin level within the gastric juice.
Common location-
Peptic ulcers commonly occur in the lesser curvature of the stomach and first part of duodenum. Also, in oesophagus & Meckel's diverticulum.
Clinically, a distinctive diagnosis of acute'and chronic peptic ulcers is difficult. Symptoms vary based on the conditions viz., whether the ulceration of gastric and duodenal mucosa is superficial or deep. Both are important as both can perforate and bleed.
Inspite of great research works, the cause for peptic ulceration remains a mystery. Though it is clear that increased acid levels leads to peptic ulceration as in example Zollinger-Ellison syndrome, in certain subjects the acid levels are normal or in some cases lower than normal levels.
Therefore increased acid levels is not the only cause for peptic ulceration. Genetic predisposition, susceptibility of people of blood group ‘O' and stress etc have varying roles in the causation of ulcers.
Now a days, infection with Helicobacter pylori has been Widely accepted as the important cause for the development of Peptic ulcers.
Another important cause is the excessive use of NSAIDs.
Cigarette smoking increases one's susceptibility of developing peptic ulcers.
For the causation of peptic ulcers, a state of increased secretion of acid as well as pepsin, is a pre-requiste. Patients with duodenal ulcer have a higher average pepsin level within the gastric juice.
Common location-
Peptic ulcers commonly occur in the lesser curvature of the stomach and first part of duodenum. Also, in oesophagus & Meckel's diverticulum.
Clinically, a distinctive diagnosis of acute'and chronic peptic ulcers is difficult. Symptoms vary based on the conditions viz., whether the ulceration of gastric and duodenal mucosa is superficial or deep. Both are important as both can perforate and bleed.
Inspite of great research works, the cause for peptic ulceration remains a mystery. Though it is clear that increased acid levels leads to peptic ulceration as in example Zollinger-Ellison syndrome, in certain subjects the acid levels are normal or in some cases lower than normal levels.
Therefore increased acid levels is not the only cause for peptic ulceration. Genetic predisposition, susceptibility of people of blood group ‘O' and stress etc have varying roles in the causation of ulcers.
Now a days, infection with Helicobacter pylori has been Widely accepted as the important cause for the development of Peptic ulcers.
Another important cause is the excessive use of NSAIDs.
Cigarette smoking increases one's susceptibility of developing peptic ulcers.
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